Fibrosis quantification in Hypertensive Heart Disease with LVH and Non-LVH: Findings from T1 mapping and Contrast-free Cardiac Diffusion-weighted imaging

Fibrosis quantification in Hypertensive Heart Disease with LVH and Non-LVH: Findings from T1 mapping and Contrast-free Cardiac Diffusion-weighted imaging

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Abstract This study assessed the extent of fibrosis and the Anti-Itch and Antifungals relationship between the ADC value and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH) and hypertensive patients without LVH (HTN non-LVH) using cardiac diffusion-weighted imaging and T1 mapping.T1 mapping was performed in 13 HTN LVH (mean age, 56.23 ± 3.30 years), 17 HTN non-LVH (mean age, 56.

41 ± 2.78 years), and 12 normal control subjects (mean age, 55.67 ± 3.08 years) with 3.

0 T MRI using cardiac diffusion-weighted imaging and T1 mapping.HTN LVH subjects had higher native T1 (1233.12 ± 79.01) compared with controls (1133.

88 ± 27.40) (p < 0.05).HTN LVH subjects had higher ECV (0.

28 ± 0.03) compared with HTN non-LVH subjects (0.26 ± 0.02) or controls (0.

24 ± 0.03) (p < 0.05).HTN LVH subjects had higher ADC (2.

23 ± 0.34) compared with HTN non-LVH subjects (1.88 ± 0.27) or controls (1.

61 ± 0.38), (p < 0.05).Positive associations were noted between LVMI and ADC (Spearman = 0.

450, p < 0.05) and between LVMI and ECV (Spearman = 0.181, p < 0.05).

ADC was also related to an increase in ECV (R2 = 0.210).Increased levels of ADC were associated with reduced peak systolic and early diastolic circumferential strain rates across all subjects.Contrast-free DW-CMR Ginger Jar is an alternative sequence to ECV for the evaluation of fibrosis extent in HTN LVH and HTN non-LVH, while native T1 has limited value.